Dimethylamine → HCID 58504091, compound

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Reaction Steps

A mixture of the compound prepared in Example 152 (500 mg) and dimethylamine (1.8 mL) in tetrahydrofuran (3 mL) was stirred at room temperature for 30 minutes. The mixture was partitioned between a saturated aqueous sodium bicarbonate solution and ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:1 then ethyl acetate=1) to obtain the title compound (191 mg) having the following physical data. 1H NMR (CDCl3): δ 8.63-8.59 (m, 1H), 8.34-8.25 (m, 1H), 7.84-7.76 (m, 1H), 7.40-7.33 (m, 1H), 4.01 (s, 2H), 3.91 (m, 3H), 2.41 (s, 6H);

Provenance & Evidence