Tetrabutylammonium Fluoride → HCID 58504042, compound

Participants

Reaction Steps

The compound prepared in Example 209 (0.032 g) was suspended in tetrahydrofuran (10 mL) and aqueous tetrabutylammonium fluoride solution (1 mol/L; 0.103 mL) added dropwise to the reaction mixture. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The combined organics were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude material, which was purified by preparative TLC, (eluant: 10% (9:1 methanol/concentrated ammonium hydroxide)/ethyl acetate) to furnish the title compound (0.020 g) having the following physical properties.

Provenance & Evidence