Ammonia → HCID 58504121, compound

HRID 2407738Notes

Reaction equation

HRID 2407738 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8](=[O:29])[NH:9][CH2:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][C:18]3[S:22][C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[N:20][CH:19]=3)[CH2:13][CH2:12]2)[N:5]=[C:4]([C:30]([O:32]C)=O)[C:3]=1[C:34]#[N:35].[NH3:36]>CO>[NH2:1][C:2]1[C:3]([C:34]#[N:35])=[C:4]([C:30]([NH2:36])=[O:32])[N:5]=[C:6]([C:8]([NH:9][CH2:10][CH:11]2[CH2:12][CH2:13][N:14]([CH2:17][C:18]3[S:22][C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[N:20][CH:19]=3)[CH2:15][CH2:16]2)=[O:29])[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58504218HCID 58504218, compound

Product 1

HCID 58504121HCID 58504121, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

The compound prepared in Example 233 (0.057 g) was suspended in methanol (4 mL) and 7 M ammonia solution in methanol (4 mL) was added. After stirring overnight at room temperature, the reaction was concentrated to provide the title compound (0.053 g) with the following physical data.

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-df7d2697b0f5480692bc69a1a3caf7e7
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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