Nitric Acid → HCID 58504175, compound

Participants

Reaction Steps

2-Amino-6-chloronicotinic acid (0.479 g) [Helvetica Chimica Acta (1976), 59(1), 222-9] was dissolved in concentrated sulfuric acid (5 mL) and cooled in an ice-saltwater bath and 2.5 mL of fuming nitric acid was then added dropwise with stirring. The ice bath was removed and the reaction mixture was stirred at ambient temperature for 8 hours. The mixture was then added dropwise to a saturated sodium bicarbonate solution (200 mL). The mixture was acidified with 9M aqueous sulfuric acid to pH 2. The solid that formed was filtered and rinsed with water to obtain the title compound (0.340 g) having the following physical data.

Provenance & Evidence