Potassium Cyanide → HCID 58504220, compound

Participants

Reaction Conditions

Reaction Steps

The compound prepared in Example 238 (0.130 g) and potassium cyanide (0.195 g) were combined in N,N-dimethylformamide (3 mL) and water (0.5 mL) was added. The reaction mixture was heated at 90° C. for 3 hours. The mixture was diluted with water and extracted with ethyl acetate. The aqueous layer was cautiously acidified with 1N hydrochloric acid to pH 1 to 2. It was then extracted with ethyl acetate. These extracts were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated to obtain the title compound (0.105 g) having the following physical data.

Provenance & Evidence