Diisopropylethylamine → HCID 66989303, compound

Participants

Reaction Steps

A solution of 4-amino-5-cyano-6-ethoxypicolinic acid (0.038 g) in N,N-dimethylformamide (2 mL) was treated with 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (0.039 g), 1-hyroxybenzotriazole hydrate (0.031 g), followed by diisopropylethylamine (0.096 mL) at room temperature. After stirring for 15 minutes, the compound prepared in Example 244 (0.079 g) was added. Stirring was continued overnight, and the resulting mixture was washed with water, and the product extracted with ethyl acetate. The organic layer was separated, filtered, evaporated in vacuo and the residue triturated in 1:1 hexane-diethyl ether. The precipitated solids were collected by filtration to provide the title compound (0.041 g) having the following physical data.

Provenance & Evidence