tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamate → HCID 70667976, compound

HRID 2407751Notes

Reaction equation

HRID 2407751 reaction equation
[OH:1][C:2]1([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]1[S:24][C:25]([CH:28]=O)=[CH:26][N:27]=1>>[OH:1][C:2]1([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH2:7][CH2:6][N:5]([CH2:28][C:25]2[S:24][C:23]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][N:17]=3)=[N:27][CH:26]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 10868112tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamateHCID 534037721083317-25-2

Product 1

HCID 70667976HCID 70667976, compound

Procedure

According to the same procedure described in Example 101, starting with the compound prepared in Example 251 instead of the compound prepared in Example 226 and the compound prepared in Example 139 instead of 2-phenylthiazole-5-carbaldehyde, the title compound having the following physical data was obtained.

Sources & evidence

ORD record
ord-e195638167c14b2090a56ae0314b2b76
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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