反应详情

To a solution of the compound prepared in Example 255 (0.500 g) in dioxane (31 mL) and water (3 mL) was treated with sodium azide (0.143 g) at room temperature. The mixture was refluxed overnight. The solvent was evaporated in vacuo and the residue was distributed between ethyl acetate and water. The aqueous layer was extracted with more ethyl acetate, dried and evaporated in vacuo to obtain the title compound (0.534 g) having the following physical data.

1. temperatureThe mixture was refluxed overnight
2. customThe solvent was evaporated in vacuo
3. extractionThe aqueous layer was extracted with more ethyl acetate
4. customdried
5. customevaporated in vacuo