HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 4-Hydroxyquinoline-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 5712530 | HCID 5712530 | — |
| Solvent | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Product | Methyl 4-Hydroxyquinoline-2-carboxylate | HCID 821167 | 4.3% |
Reaction Conditions
| Temperature | 250 °C |
|---|
Reaction Steps
A mixture of the compound prepared in Example 271 (0.980 g) in Dowtherm A (trade mark; 1 mL) was heated at 250° C. for 15 minutes. The mixture was cooled to room temperature and shaken between dichloromethane and water. The organic layer was dried, concentrated in vacuo and purified by column chromatography on silica gel (1-5% methanol in dichloromethane) to obtain the title compound (0.036 g) having the following physical data.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809538B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-cdde8fd665754f09b37229978437d7e6 |
| Source note | uspto-grants-2014_08 |