4-Aminoquinoline-2-carboxylic acid → HCID 66989751, compound

HRID 2407761Notes

Reaction equation

HRID 2407761 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([OH:14])=O)[CH:3]=1.[C:15]1([C:21]2[CH:25]=[C:24]([CH2:26][N:27]3[CH2:32][CH2:31][CH:30]([CH2:33][NH2:34])[CH2:29][CH2:28]3)[O:23][N:22]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([NH:34][CH2:33][CH:30]2[CH2:29][CH2:28][N:27]([CH2:26][C:24]3[O:23][N:22]=[C:21]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:25]=3)[CH2:32][CH2:31]2)=[O:14])[CH:3]=1

Participants

3

Reactant 2

HCID 225039574-Aminoquinoline-2-carboxylic acidHCID 58504252HCID 58504252, compound

Product 1

HCID 66989751HCID 66989751, compound

Procedure

According to the same procedure described in Example 225, using the compound prepared in Example 275 instead of 4-amino-5-cyano-6-ethoxypicolinic acid, and using 1-{1-[(3-phenyl-5-isoxazolyl)methyl]-4-piperidinyl}methanaminethe compound prepared in Example 9 instead of tert-butyl 4-(aminomethyl)piperidine-1-carboxylate the title compound having the following physical data was obtained.

Sources & evidence

ORD record
ord-c372f36007f64d2c94e9c9a1bce97c3f
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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