HCID 58504252, compound → HCID 58504292, compound

HRID 2407766Notes

Reaction equation

HRID 2407766 reaction equation
[NH2:1][C:2]1[C:3]([C:11]([OH:13])=O)=[N:4][C:5]([O:8][CH2:9][CH3:10])=[CH:6][CH:7]=1.[C:14]1([C:20]2[CH:24]=[C:23]([CH2:25][N:26]3[CH2:31][CH2:30][CH:29]([CH2:32][NH2:33])[CH2:28][CH2:27]3)[O:22][N:21]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[NH2:1][C:2]1[C:3]([C:11]([NH:33][CH2:32][CH:29]2[CH2:28][CH2:27][N:26]([CH2:25][C:23]3[O:22][N:21]=[C:20]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:24]=3)[CH2:31][CH2:30]2)=[O:13])=[N:4][C:5]([O:8][CH2:9][CH3:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58504252HCID 58504252, compoundHCID 66990904HCID 66990904, compound

Product 1

HCID 58504292HCID 58504292, compound

Procedure

According to the same procedure described in Example 225, using the compound prepared in Example 282 instead of 4-amino-5-cyano-6-ethoxypicolinic acid, and using the compound prepared in Example 9 instead of tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, the title compound having the following physical data was obtained.

Sources & evidence

ORD record
ord-80c2cea597a742f1a5ebf56e46783243
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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