HCID 23503177, compound → HCID 66989569, compound

HRID 2407770Notes

Reaction equation

HRID 2407770 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH2:12][CH3:13])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[C:14]1([C:20]2[CH:24]=[C:23]([CH2:25][N:26]3[CH2:31][CH2:30][CH:29]([CH2:32][NH2:33])[CH2:28][CH2:27]3)[O:22][N:21]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[NH2:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH2:12][CH3:13])=[C:6]([CH:10]=1)[C:7]([NH:33][CH2:32][CH:29]1[CH2:28][CH2:27][N:26]([CH2:25][C:23]2[O:22][N:21]=[C:20]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:24]=2)[CH2:31][CH2:30]1)=[O:9]

Participants

3

Reactant 2

HCID 23503177HCID 23503177, compoundHCID 58504252HCID 58504252, compound

Product 1

HCID 66989569HCID 66989569, compound

Procedure

According to the same procedure described in Example 225, using the compound prepared in Example 288 instead of 4-amino-5-cyano-6-ethoxypicolinic acid, and using the compound prepared in Example 9 instead of tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, the title compound having the following physical data was obtained.

Sources & evidence

ORD record
ord-6d0550c27f114fac92de315f35d0564d
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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