Methylamine → HCID 66989536, compound

Participants

Reaction Steps

The compound prepared in Example 303 (0.100 g) was suspended in toluene (10 mL) and oxalyl chloride (0.085 mL) added. The reaction mixture was stirred at room temperature for 2 hours. Methylamine solution (2 mol/L; 3.672 mL) was added and the reaction mixture stirred at room temperature for 1 hour. The reaction mixture was then partitioned between saturated aqueous sodium bicarbonate solution and ethyl acetate. The organics were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude material (0.173 g), which was used without further purification possessing the following physical data.

Provenance & Evidence