Methyl chloroglyoxylate → HCID 58504089, compound

Participants

Reaction Steps

To a solution of the compound prepared in Example 326 (620 mg) in dichloromethane (10.0 mL) at 0° C. was added diisopropylethylamine (0.82 mL) followed by methyl 2-chloro-2-oxoacetate (0.22 mL). The reaction was allowed to warm to room temperature and then stirred for 2 hours. The solution was diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate solution and brine. The organics were dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude material, which was purified by flash column chromatography (eluant: 50% ethyl acetate/hexane) to furnish the title compound (722 mg) with the following physical properties.

Provenance & Evidence