Trimethylsilyl iodide → HCID 58503923, compound

Participants

Reaction Steps

A solution of the compound prepared in Example 330 (37 mg) in acetonitrile (1 mL) was treated with iodotrimethylsilane (0.015 mL) for 30 minutes at room temperature. The solution was diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate solution and brine. The organics were dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude material, which was purified by preparative thin layer chromatography (eluant: 20% (9:1 methanol/concentrated ammonium hydroxide)/ethyl acetate) to furnish the title compound (5 mg) with the following physical properties.

Provenance & Evidence