Potassium Carbonate → HCID 58504305, compound

Participants

Reaction Conditions

Reaction Steps

The compound prepared in Example 336 (30 mg), pyridin-2-ol (0.0124 g), copper(I) iodide (0.0068 g), trans-N1,N2-dimethylcyclohexane-1,2-diamine (0.0113 mL), and potassium carbonate (0.0173 g) were combined in N,N-dimethylformamide (0.5 mL). The reaction mixture was purged with argon for 5 minutes and then heated at 110° C. for 4 hours. The reaction mixture was diluted with ethyl acetate (15 mL) and passed through a plug of silica gel, eluting with ethyl acetate. The eluent was concentrated and the residue was purified by column chromatography on silica gel (ethyl acetate:methanol=19:1) to obtain the title compound (11 mg) having the following physical data.

Provenance & Evidence