3-Cyano-2-pyridone → 955399-19-6

HRID 2407796Notes

Reaction equation

HRID 2407796 reaction equation
[O:1]=[C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][NH:3]1.[NH4+]=[S:11]>CO>[O:1]=[C:2]1[C:7]([C:8](=[S:11])[NH2:9])=[CH:6][CH:5]=[CH:4][NH:3]1

Participants

3

Reactant 1

HCID 5775433-Cyano-2-pyridone

Product 1

HCID 43165067955399-19-6

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
130 °C

Procedure

To a suspension of 2-oxo-1,2-dihydropyridine-3-carbonitrile (0.211 g) in methanol (14 mL) was added a 40% aqueous solution of ammonium sulfide (0.50 mL). The reaction mixture was heated at 130° C. in a microwave reactor for 2 hours. The reaction mixture was concentrated. The residue obtained was triturated with methanol and the solid filtered to obtain the title compound (0.174 g) having the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customThe residue obtained
  3. customwas triturated with methanol
  4. filtrationthe solid filtered

Sources & evidence

ORD record
ord-d76337db382d4ab8aaa875a0da4c4660
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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