Cesium carbonate → HCID 58503974, compound

Participants

Reaction Steps

The compound prepared in Example 334 (0.009 g), 5-(bromomethyl)-2,2′-bipyrdine (0.008 g, prepared according to the reported preparation in Journal of the American Chemical Society, 2006, 128(1), 250-256) and cesium carbonate (0.019 g) were heated to 80° C. for 16 hours in N,N-dimethylformamide (2 mL). The reaction mixture was partitioned between saturated aqueous sodium bicarbonate and ethyl acetate. The organics were washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to afford the crude material, which was purified by flash column chromatography (eluant: 1-4% (9:1 methanol:ammonium hydroxide)/ethyl acetate) to furnish the title compound (0.006 g) having the following physical data.

Provenance & Evidence