Cyclopropanemethanol → HCID 58504287, compound

HRID 2407806Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6](Cl)[N:5]=[C:4]([C:11]([NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[S:26][C:25]([C:27]4[C:32]([F:33])=[CH:31][CH:30]=[CH:29][C:28]=4[F:34])=[N:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:12])[CH:3]=1.[CH:35]1([CH2:38][OH:39])[CH2:37][CH2:36]1>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:39][CH2:38][CH:35]2[CH2:37][CH2:36]2)[N:5]=[C:4]([C:11]([NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[S:26][C:25]([C:27]4[C:32]([F:33])=[CH:31][CH:30]=[CH:29][C:28]=4[F:34])=[N:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:12])[CH:3]=1

Participants

Reactant 2

HCID 75644Cyclopropanemethanol

HCID 58504177HCID 58504177, compound

Product 1

HCID 58504287HCID 58504287, compound

Procedure

According to the same procedure described in Example 204, using the compound prepared in Example 399 instead of the compound prepared in Example 215 and cyclopropylmethanol instead of 1-cyclopropylethanol, the title compound having the following physical data was obtained.

Sources & evidence

ORD record: ord-3c12ae1d6b9f4cf88d3811f9ef906f80
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809538B2

Reaction notes

Loading…