反应详情

A solution of the compound prepared in Example 427 (0.025 g) in methanol (1 mL) was treated with sodium hydroxide (0.11 mL) and refluxed for 18 hours. This material was evaporated in vacuo and residue dissolved in water and acidified with 1N hydrochloric acid. The product was extracted with ethyl acetate, dried, and evaporated in vacuo to provide the title compound (0.003 g) having the following physical data.

1. temperaturerefluxed for 18 hours
2. customThis material was evaporated in vacuo and residue
3. dissolutiondissolved in water
4. extractionThe product was extracted with ethyl acetate
5. customdried
6. customevaporated in vacuo