反应详情

A solution of the compound prepared in Example 430 (0.025 g) in methanol (1 mL) was treated with sodium hydroxide (0.094 mL) and refluxed for 3 hours. This material was evaporated in vacuo and residue dissolved in water and acidified with 1 mol/L hydrochloric acid. The product was extracted with ethyl acetate, dried, and evaporated in vacuo to provide the title compound (0.011 g) with the following physical data.

1. temperaturerefluxed for 3 hours
2. customThis material was evaporated in vacuo and residue
3. dissolutiondissolved in water
4. extractionThe product was extracted with ethyl acetate
5. customdried
6. customevaporated in vacuo