Diisobutylaluminumhydride → HCID 58504153, compound

Participants

Reaction Steps

To a solution of the compound prepared in Example 439 (12.5 g) in dichloromethane (300 mL) at −95° C. was added a 1 mol/L solution of diisobutylaluminium hydride (48.5 mL) in hexanes dropwise slowly. The mixture was stirred for 3 hours and then quenched with methanol (50 mL). A solution of Rochelle's salt was then added dropwise. The mixture was warmed to room temperature and extracted with ethyl acetate. The combined extracts were washed with water and then concentrated. The residue was purified by column chromatography on silica gel (petroleum ether:ethyl acetate=5:1) to obtain the title compound (4.3 g) having the following physical data.

Provenance & Evidence