HCID 86678260, compound → HCID 86678261, compound

Participants

Reaction Steps

Diethyl 2-(2-azidoethoxy)ethylphosphonate (1 eq) was dissolved in EtOH (0.1 M). Pd(OH)2 (0.05 eq) was added to the reaction. Hydrogen gas was introduced via a balloon; and the reaction was stirred for 2 hours at room temperature. The mixture was filtered through Celite and washed with MeOH. The solvent was removed en vaccuo and the crude material was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-10% MeOH/DCM with 2% NH3 in methanol to give the product as colorless oil.

Provenance & Evidence