HCID 86678284, compound → HCID 86678285, compound

Participants

Reaction Steps

(6S,9R,13R)-9-(((9H-fluoren-9-yl)methoxy)carbonylamino)-13-(dodecanoyloxy)-6-methyl-8,16-dioxo-4,15-dioxa-11-thia-7-azaheptacosylphosphonic acid diethyl ester (1 eq, from the previous step) in was dissolved in 20% piperidine in THF (0.1 M) and stirred at room temperature for 2 hours. The viscous reaction mixture was diluted in methyl tert-butyl ether and ethyl acetate. The organic layer was washed with 1:1 saturated aqueous NH4Cl/water (2×), brine, dried over anhydrous Na2SO4, and concentrated en vaccuo. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using a gradient of 0-5% methanol in DCM to give the product.

Provenance & Evidence