HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Diethyl 3-(4-(2-aminoethyl)phenoxy)propylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 4-(3-(diethoxyphosphoryl)propoxy)phenethylcarbamate | HCID 86678287 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Diethyl 3-(4-(2-aminoethyl)phenoxy)propylphosphonate | HCID 86678288 | — |
Reaction Steps
To a solution of tert-butyl 4-(3-(diethoxyphosphoryl)propoxy)phenethylcarbamate (1 eq) in DCM (0.14 M) was added 4M HCl in dioxane (50 eq). The resulting mixture was stirred at room temperature for 2 hours. The mixture was concentrated en vaccuo. The crude material was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-15% MeOH/DCM to give the product as a yellowish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08808703B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-437ec932b2a74bde83a50ede1fa3df84 |
| Source note | uspto-grants-2014_08 |