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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2407902Generated: October 30, 2026

Triethyl Phosphate → Diethyl 2-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)ethylphosphonate

https://huagongshe.com/reaction/2407902

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethyl PhosphateHCID 6535—
ReactantEthane, 1,1'-oxybis[2-(2-iodoethoxy)-HCID 11101742—
ProductDiethyl 2-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)ethylphosphonateHCID 86678292—

Reaction Conditions

Temperature160 °C

Reaction Steps

1-iodo-2-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)ethane (1 eq) was mixed with triethyl phosphate (1 eq) then heated to 160° C. for 20 minutes by microwave. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-10% MeOH/DCM to give the product as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08808703B2
Source datasetuspto-grants-2014_08
ORD IDord-85f9b56d57da4775ad9eda82e0aa1b97
Source noteuspto-grants-2014_08