HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-tert-butyl (1-((2-(2-(2-(diethoxyphosphoryl)ethoxy)ethoxy)ethyl)amino)-1-oxopropan-2-yl)carbamate → (S)-diethyl (2-(2-(2-(2-aminopropanamido)ethoxy)ethoxy)ethyl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-tert-butyl (1-((2-(2-(2-(diethoxyphosphoryl)ethoxy)ethoxy)ethyl)amino)-1-oxopropan-2-yl)carbamate | HCID 86678316 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | (S)-diethyl (2-(2-(2-(2-aminopropanamido)ethoxy)ethoxy)ethyl)phosphonate | HCID 86678315 | — |
Reaction Steps
A solution of (S)-tert-butyl (1-((2-(2-(2-(diethoxyphosphoryl)ethoxy)ethoxy)ethyl)amino)-1-oxopropan-2-yl)carbamate (1 eq) in 4N HCl/dioxane (0.4 M) was stirred at 25° C. for 1 hour. The reaction mixture was concentrated en vaccuo to give the title product as a colorless viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08808703B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-93eec979db2848db932f1b951e8b4cde |
| Source note | uspto-grants-2014_08 |