反应详情

A solution of (R)-tert-butyl 2-(benzyloxycarbonylamino)-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoate in 30% TFA in DCM (0.3 M) was stirred at room temperature until complete deprotection of the tert-butyl group (4 hours). The reaction was diluted with DCM and concentrated with a stream of nitrogen. The reaction mixture was then diluted in MTBE and washed once with 1M citric acid (adjusted to pH3). The organic layer was dried over anhydrous Na2SO4 and concentrated en vaccuo. The resulting waxy solid was used without further purification.

1. concentrationconcentrated with a stream of nitrogen
2. additionThe reaction mixture was then diluted in MTBE
3. washwashed once with 1M citric acid (adjusted to pH3)
4. dry with materialThe organic layer was dried over anhydrous Na2SO4
5. concentrationconcentrated en vaccuo
6. customThe resulting waxy solid was used without further purification