Hydrochloric Acid → HCID 70496057, compound

Participants

Reaction Steps

To a stirred mixture solution of 2-(3-methoxycarbonyl-phenyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester (3.7 g, 10.0 mmol) in tetrahydrofuran (20.0 mL) was added 4.0 N lithium hydroxide in water (12.0 mL). The reaction mixture was stirred at room temperature for 6 h. The mixture was neutralized with a 3 N aqueous hydrochloric acid solution and extracted with ethyl acetate (2×100 mL), washed with water, dried over anhydrous sodium sulfate and then concentrated in vacuo to afford 2-(3-carboxy-phenyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester (3.6 g, quant.) as a light white solid which was used for next step without further purification: MS (ESI) M+1=354.1.

Provenance & Evidence