HCID 58560983, compound → HCID 46897030, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Step A (50 mg, 0.087 mmol) in water (0.5 mL) and acetonitrile (0.5 mL) at room temperature was added palladium (II) chloride (1.5 mg, 8.7 μmol). The resulting mixture was stirred at 50° C. for 12 hours. After cooling to room temperature, the mixture was extracted with EtOAc, then the organic layer was filtered through celite. The filtrate was concentrated, then the resulting residue was purified by PTLC eluting with 5% MeOH/DCM+0.1% HOAc to afford the title compound. NMR (500 MHz, CD3OD): δ 7.74 (d, J=8.0 Hz, 2H); 7.36 (d, J=8.0 Hz, 2H); 7.31 (d, J=8.0 Hz, 2H); 7.24 (d, J=9.0 Hz, 2H); 7.22 (s, 1H); 7.12 (s, 1H); 7.09 (s, 1H); 5.64 (d, J=6.5 Hz, 1H); 3.63 (t, J=9.2 Hz, 2H); 3.26-3.23 (m, 1H); 2.62 (t, J=9.5 Hz, 2H); 2.10-2.05 (m, 2H); 2.00-1.95 (m, 2H); LC3 3.59 min. (M+H)+ 579.

Provenance & Evidence