Triethylamine → HCID 86661264, compound

Participants

Reaction Steps

To a cold solution of geranyl amine (7 g) and triethyl amine (6 g) in THF (50 ml) was added dropwise a solution of 2-acetoxypropanoyl chloride (9 g) in dichloromethane (15 ml) at a temperature between 6° C. and 13° C. over a period of 20 minutes. Stirring was continued at room temperature for 2 hrs. The white precipitate (triethylamine HCl salt) was filtered and the filtrate was evaporated. The residue was dissolved in DCM (100 ml), washed twice with 50 ml of aqueous 5% HCl solution and twice with water (2×50 ml) and evaporated to dryness to yield 12.6 g of a colourless oil. The yield was 90%, the purity was 95% according to NMR analysis.

Provenance & Evidence