Ammonia → Benzeneacetamide

HRID 2408239Notes

Reaction equation

HRID 2408239 reaction equation
[C:1]1([CH2:7][C:8]([O-:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1C=C([N:18]2C=CC(C(F)(F)F)=N2)C=CC=1C(F)(F)CNC(C1C(C(F)(F)F)=CC=CN=1)=O.N>CO>[C:1]1([CH2:7][C:8]([NH2:18])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 4409936PhenylacetateHCID 86707230HCID 86707230, compound

Product 1

HCID 7680Benzeneacetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of ethyl 2-chloro-α,α-difluoro-4-[3-trifluoromethyl)-1H-pyrazol-1-yl]benzeneacetate (i.e. the product of Step B; 500 mg, 1.35 mmol in methanol was added dropwise ammonia in methanol (2 M, 3.37 mL, 6.75 mmol), and the resulting mixture was stirred for 24 h at room temperature. The solvent was removed under reduced pressure to afford crude 2-chloro-α,α-difluoro-4-[3-trifluoromethyl)-1H-pyrazol-1-yl]benzeneacetamide, which was used without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-4bdbffdfa7dd4df997a8745e65321cc9
Source dataset
uspto-grants-2014_08
Patent number
US08815772B2

Reaction notes

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