Lithium hydroxide, monohydrate → HCID 86660070, compound

Participants

Reaction Steps

To a solution of ethyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}-4-fluoropiperidin-4-yl)-1,3-thiazole-4-carboxylate (300 mg) in tetrahydrofuran (3 ml) and water (1 ml) was added, at room temperature, lithium hydroxide monohydrate (40 mg). The mixture was stirred at room temperature for 3 hours, and then ice-cold 1N HCl solution was added. The aqueous phase was extracted with ethyl acetate and then the combined organic phases were dried over sodium sulphate. The solids were filtered off and the solvent was distilled off. This gave 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}-4-fluoropiperidin-4-yl)-1,3-thiazole-4-carboxylic acid (230 mg).

Provenance & Evidence