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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2408291Generated: October 31, 2026

Rosiglitazone → Pioglitazone, (R)-

https://huagongshe.com/reaction/2408291

Reaction equation

Participants

RoleNameHCIDCharge
ReactantRosiglitazoneHCID 77999—
Reactant(E)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dioneHCID 14211277—
ProductPioglitazone, (R)-HCID 29010894—

Reaction Steps

Biocatalytic reduction of 5-[1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-thiazolidine-2,4-dione was investigated using literature procedures described for Rosiglitazone (J. Chem. Soc. Perkin Trans. I, 1994, 3319-3324).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08815837B2
Source datasetuspto-grants-2014_08
ORD IDord-3503ba0ab560487a96da1eb13a5c50d6
Source noteuspto-grants-2014_08