HCID 58377093, compound → HCID 68282905, compound

HRID 2408295Notes

Reaction equation

HRID 2408295 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C@:8]2([CH3:18])[C:14]([F:16])([F:15])[CH2:13][O:12][CH2:11][C:10]([NH2:17])=[N:9]2)[CH:7]=1.[C:20]([C:23]1[CH:24]=[C:25]([F:32])[C:26]([C:29]([OH:31])=[O:30])=[N:27][CH:28]=1)(=[O:22])[NH2:21]>>[CH:29]([OH:31])=[O:30].[NH2:17][C:10]1[CH2:11][O:12][CH2:13][C:14]([F:15])([F:16])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:29]([C:26]3[C:25]([F:32])=[CH:24][C:23]([C:20]([NH2:21])=[O:22])=[CH:28][N:27]=3)=[O:30])[CH:3]=[CH:4][C:5]=2[F:19])([CH3:18])[N:9]=1

Participants

3

Reactant 2

HCID 58377093HCID 58377093, compoundHCID 58562966(R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine

Product 1

HCID 68282905HCID 68282905, compound

Procedure

The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A9B) and 5-carbamoyl-3-fluoro-pyridine-2-carboxylic acid (prepared according to Hori, A. et al., Int. Patent Application Publ. No. WO2009151098) yielded the title compound as an off-white amorphous material. MS (ISP): m/z=440.2 [M+H]+.

Sources & evidence

ORD record
ord-4562d326ba6b4b358b9cd4bd7b601fe9
Source dataset
uspto-grants-2014_08
Patent number
US08815841B2

Reaction notes

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