HCID 57827797, compound → HCID 71254280, compound

HRID 2408296Notes

Reaction equation

HRID 2408296 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C@:8]2([CH3:18])[C:14]([F:16])([F:15])[CH2:13][O:12][CH2:11][C:10]([NH2:17])=[N:9]2)[CH:7]=1.[S:20]1[CH:24]=[CH:23][N:22]=[C:21]1[C:25]1[CH:26]=[CH:27][C:28]([C:31]([OH:33])=[O:32])=[N:29][CH:30]=1>>[CH:31]([OH:33])=[O:32].[NH2:17][C:10]1[CH2:11][O:12][CH2:13][C:14]([F:15])([F:16])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:31](=[O:32])[C:28]3[CH:27]=[CH:26][C:25]([C:21]4[S:20][CH:24]=[CH:23][N:22]=4)=[CH:30][N:29]=3)[CH:3]=[CH:4][C:5]=2[F:19])([CH3:18])[N:9]=1

Participants

3

Reactant 2

HCID 57827797HCID 57827797, compoundHCID 58562966(R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine

Product 1

HCID 71254280HCID 71254280, compound

Procedure

The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A9B) and 5-thiazol-2-yl-pyridine-2-carboxylic acid (prepared according to Suzuki, Y. et al., Int. Patent Application Publ. No. WO2009091016) yielded the title compound as an off-white amorphous material. MS (ISP): m/z=462.2 [M+H]+.

Sources & evidence

ORD record
ord-3478da8802ed407d8a713946c65fc82c
Source dataset
uspto-grants-2014_08
Patent number
US08815841B2

Reaction notes

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