HCID 57827600, compound → HCID 68282765, compound

HRID 2408297Notes

Reaction equation

HRID 2408297 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C@:8]2([CH3:18])[C:14]([F:16])([F:15])[CH2:13][O:12][CH2:11][C:10]([NH2:17])=[N:9]2)[CH:7]=1.[CH3:20][S:21][C:22]1[N:23]=[CH:24][C:25]([C:28]([OH:30])=[O:29])=[N:26][CH:27]=1>>[CH:28]([OH:30])=[O:29].[NH2:17][C:10]1[CH2:11][O:12][CH2:13][C:14]([F:15])([F:16])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:28]([C:25]3[CH:24]=[N:23][C:22]([S:21][CH3:20])=[CH:27][N:26]=3)=[O:29])[CH:3]=[CH:4][C:5]=2[F:19])([CH3:18])[N:9]=1

Participants

3

Reactant 2

HCID 57827600HCID 57827600, compoundHCID 58562966(R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine

Product 1

HCID 68282765HCID 68282765, compound

Procedure

The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A9B) and 5-methylsulfanyl-pyrazine-2-carboxylic acid (prepared according to Suzuki, Y. et al., Int. Patent Application Publ. No. WO2009091016) yielded the title compound as an off-white solid. MS (ISP): m/z=426.1 [M+H]+.

Sources & evidence

ORD record
ord-317afc83c1424719aab9a97a45adbe4d
Source dataset
uspto-grants-2014_08
Patent number
US08815841B2

Reaction notes

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