HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57475876, compound → HCID 71254340, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57475876 | HCID 57475876 | — |
| Reactant | (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine | HCID 58562966 | — |
| Product | HCID 71254340 | HCID 71254340 | — |
Reaction Steps
The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A9B) and 5-cyclopropylethynyl-pyridine-2-carboxylic acid (prepared according to Suzuki, Y. et al., Int. Patent Application Publ. No. WO2009091016) yielded the title compound as an off-white solid. MS (ISP): m/z=443.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815841B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-351259e650eb4a07bff94597e26950a3 |
| Source note | uspto-grants-2014_08 |