Methanol → [4-(2-Cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6-yl-ethynyl)phenyl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Tetrahydrofuran	HCID 8028	—
Reactant	Lithium hydroxide, monohydrate	HCID 168937	—
Reactant	[4-(2-Cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6ylethynyl)-phenyl]-acetic acid methyl ester	HCID 69548441	—
Solvent	Water	HCID 962	—
Product	[4-(2-Cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6-yl-ethynyl)phenyl]-acetic acid	HCID 10109120	—

Reaction Steps

Following general procedure J and using [4-(2-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6ylethynyl)-phenyl]-acetic acid methyl ester (Compound 23, 0.01 g, 0.027 mmol), methanol (1 mL), tetrahydrofuran (1 mL), water (0.5 mL) and lithium hydroxide monohydrate (0.042 g, 1 mmol) the title compound was obtained as a pale yellow solid foam (0.0065 g, 68%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06855512B2
Source dataset	uspto-grants-2005_02
ORD ID	ord-a4eda0be36c742ebac812f0b8ac01b6a
Source note	uspto-grants-2005_02