HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 1-(2-isopropoxyethyl)-2,2-dimethyl-7-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 7-chloro-1-(2-isopropoxyethyl)-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one | HCID 68034539 | — |
| Product | 1-(2-isopropoxyethyl)-2,2-dimethyl-7-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one | HCID 57389533 | 60% |
Reaction Steps
150 mg of 7-chloro-1-(2-isopropoxyethyl)-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one in 2 mL of morpholine are heated with the microwave oven to 80° C. for 45 mins. The crude is purified by flash chromatography on silica gel (CH2Cl2 100% to CH2Cl2/MeOH, 92/8). 0.085 g (yield=60%) of 1-(2-isopropoxyethyl)-2,2-dimethyl-7-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one are obtained as a beige solid and including the following characteristics:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815853B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-f23b64a8af494820b1c2b28a1bbce753 |
| Source note | uspto-grants-2014_08 |