Bromine → 3-bromo-6-(4-methoxyphenyl)-1H-indole

HRID 240834Notes

Reaction equation

HRID 240834 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:17]=[C:16]3[C:12]([CH:13]=[CH:14][NH:15]3)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[Br:18]Br>>[Br:18][C:13]1[C:12]2[C:16](=[CH:17][C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)=[CH:10][CH:11]=2)[NH:15][CH:14]=1

Participants

3

Reactant 2

HCID 24408BromineHCID 152927466-(4-methoxyphenyl)-1H-indole

Product 1

HCID 669550543-bromo-6-(4-methoxyphenyl)-1H-indole

Procedure

The target compound was prepared as in Preparation Example 6 using 6-(4-methoxyphenyl)-1H-indole (500 mg, 2.24 mmol) and bromine (115 μL, 2.24 mmol).

Sources & evidence

ORD record
ord-48d6a76dff56483dbe37da01fe551de0
Source dataset
uspto-grants-2014_02
Patent number
US08648089B2

Reaction notes

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