HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 21581542, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Cyclopentanone | HCID 8452 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Product | HCID 21581542 | HCID 21581542 | 85% |
Reaction Steps
7 g of cyclopentanone are solubilized in 10 mL of benzylamine. The reaction mixture is stirred for 30 mins under argon and at RT. 12.75 mL of TMSCN are added dropwise and then stirred for 1 h. They are dry evaporated. They are purified by flash chromatography on silica gel (heptane/EtOAc 99:1, to heptane/EtOAc 65:35). 14.15 g (yield=85%) of 1-(benzylamino)cyclopentanecarbonitrile are obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815853B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-dfe0af339f434e9896d9b4aa0b898468 |
| Source note | uspto-grants-2014_08 |