Propanedioic acid, monoethyl ester → HCID 136344290, compound

Participants

Reaction Conditions

Reaction Steps

1.2 g of sodium are added in a fractionated way to 15 mL of MeOH. After total dissolution, 3 g of 4,4-dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine solubilized beforehand in 5 mL of MeOH are added, and then 14.4 mL of ethyl malonate. The mixture is heated to 100° C., after 4 h of heating, the medium is dry concentrated. The obtained oil is taken up in ether. The precipitate is filtered and then the residue is taken up in 7 mL of H2O and acidified with conc.HCl down to pH 3-4. The formed precipitate is filtered, washed with ether and dried in the oven in vacuo. 1.14 g (yield=90%) of 2-hydroxy-8,8-dimethyl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one are obtained as a beige solid used as such.

Provenance & Evidence