Hydrogen Bromide → 3-Methylbutane-1,3-diamine dihydrobromide

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Reaction Steps

2.8 g of ethyl(3-amino-1,1-dimethylpropyl)carbamate are cooled with an ice bath. 9.9 mL of 33% HBr in acetic acid are added dropwise and then the mixture is refluxed with heating for 2 h. After returning to RT, the product is precipitated with Et2O, and filtered. The obtained powder is dried in the oven at 70° C. 2.34 g (yield=55%) of 3-methylbutane-1,3-diamine dihydrobromide are obtained as a white powder used as such.

Provenance & Evidence