HCID 86621688, compound → HCID 15986054, compound

HRID 2408437Notes

Reaction equation

HRID 2408437 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH:25]=[CH:24][C:23](/[CH:26]=[CH:27]/[C:28]([NH:30][O:31]C4CCCCO4)=[O:29])=[CH:22]3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:3]>CO>[OH:31][NH:30][C:28](=[O:29])/[CH:27]=[CH:26]/[C:23]1[CH:24]=[CH:25][N:21]([S:18]([C:15]2[CH:14]=[CH:13][C:12]([C:9]3[CH:10]=[CH:11][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:7][CH:8]=3)=[CH:17][CH:16]=2)(=[O:19])=[O:20])[CH:22]=1

Participants

3

Reactant 1

HCID 86621688HCID 86621688, compound

Product 1

HCID 15986054HCID 15986054, compoundYield 82.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.223 g (E)-3-[1-(4′-methanesulfonylamino-biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 6.0 ml methanol and 12.0 ml 1M aqueous HCL is stirred at ambient temperature for 24 h. The suspension is evaporated and the solid is washed with water and diisopropylether. The title compound is dried in vacuo. By this method 0.155 g light pink solid are obtained. Melting point: 160-167° C.

Workup

  1. customThe suspension is evaporated
  2. washthe solid is washed with water and diisopropylether
  3. dry with materialThe title compound is dried in vacuo

Sources & evidence

ORD record
ord-d70625545e1e45fe9a51ecca3e7b7a8d
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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