HCID 86640143, compound → HCID 15985054, compound

Participants

Reaction Steps

A mixture of 0.278 g (E)-N-(tetrahydro-pyran-2-yloxy)-3-{1-[4′-(toluene-4-sulfonylamino)-biphenyl-4-sulfonyl]-1H-pyrrol-3-yl}-acrylamide with 6.0 ml methanol and 13.0 ml 1M aqueous HCL is stirred at ambient temperature for 2 days. In case of incomplete deprotection the suspension is treated again with 1M aqueous HCL until the reaction is at completion. The mixture is evaporated and the resulting solid is washed with water and diisopropylether. The crude product is isolated by PLC plates chromatography. By this method 0.129 g of a red solid are obtained. Melting point: 119-126° C., sinter is beginning from 97° C.

Provenance & Evidence