Methanol → HCID 68528011, compound

HRID 2408440Notes

Reaction equation

HRID 2408440 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[S:11][C:10]([S:12]([N:15]3[CH:19]=[CH:18][C:17](/[CH:20]=[CH:21]/[C:22]([NH:24]OC4CCCCO4)=[O:23])=[CH:16]3)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[CH:4]=[N:3]1.C[OH:33]>>[OH:33]/[C:21](=[CH:20]/[C:17]1[CH:18]=[CH:19][N:15]([S:12]([C:10]2[S:11][C:7]([C:5]3[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=3)=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH:16]=1)/[C:22]([NH2:24])=[O:23]

Participants

3

Reactant 2

HCID 887MethanolHCID 86621690HCID 86621690, compound

Product 1

HCID 68528011HCID 68528011, compound

Procedure

A mixture of 0.099 g (E)-3-{1-[5-(1-methyl-1H-pyrazol-4-yl)-thiophene-2-sulfonyl]-pyrrol-3-yl}-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 3.0 ml methanol and 6.0 ml 1M aqueous HCL is stirred at ambient temperature for 24 h. The suspension is filtered and washed with water and ethyl acetate. The title compound is dried in vacuo. By this method 0.037 g light pink solid are obtained. Melting point: 163-166° C.

Workup

  1. filtrationThe suspension is filtered
  2. washwashed with water and ethyl acetate
  3. dry with materialThe title compound is dried in vacuo

Sources & evidence

ORD record
ord-bc6e318740b44a47afbd544d5c452d81
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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