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HRID2408444

反应详情

EQUATION

反应方程式

HRID 2408444 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1
HCID2773987

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C10H17BN2O2

结构：O=C(/C=C/c1ccn(S(=O)(=O)c2ccc(Br)cc2)c1)NOC1CCCCO1
HCID86621691

未命名化合物

PRODUCTS

生成物

1
结构：Cn1cc(-c2ccc(S(=O)(=O)n3ccc(/C=C/C(=O)NOC4CCCCO4)c3)cc2)cn1
HCID86621695

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COCCOC
溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

(E)-3-[1-(4-Bromo-benzenesulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (966 mg) and 1-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (662 mg) are dissolved in DME (35 mL) and (Ph3P)3PdCl2 (298 mg) and 2M Na2CO3-solution (3.2 mL) are added. The mixture is heated 16 h to reflux temperature. The mixture is filtered and evaporated and the crude product is purified by silica gel flash chromatography.

WORKUP

后处理

  1. temperatureThe mixture is heated 16 h
  2. temperatureto reflux temperature
  3. filtrationThe mixture is filtered
  4. customevaporated
  5. customthe crude product is purified by silica gel flash chromatography