Methylamine hydrochloride → 6-(3-bromo-6-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amine

HRID 240846Notes

Reaction equation

[Br:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][CH:9]=2)[N:4]([C:19]2[CH:24]=[C:23](Cl)[N:22]=[CH:21][N:20]=2)[CH:3]=1.Cl.[CH3:27][NH2:28]>>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][CH:9]=2)[N:4]([C:19]2[N:20]=[CH:21][N:22]=[C:23]([NH:28][CH3:27])[CH:24]=2)[CH:3]=1

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 509915463-bromo-1-(6-chloropyrimidin-4-yl)-6-(4-methoxyphenyl)-1H-indole

Product 1

HCID 509915476-(3-bromo-6-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amine

Procedure

The target compound was prepared as in Example 10 using 3-bromo-1-(6-chloropyrimidin-4-yl)-6-(4-methoxyphenyl)-1H-indole (400 mg, 0.96 mmol) and methylamine hydrochloride (326 mg, 4.8 mmol).

Sources & evidence

ORD record: ord-c8467e7bd159461bb9c767d1a72015f0
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648089B2

Reaction notes

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