N-bromobutanimide → 7-bromo-6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine

Participants

Reaction Steps

To a slurry of 6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine (1.0 g) in acetone (50 mL) was added N-bromosuccinimide (1.0 g). The reaction was stirred at rt for 2 h, until complete conversion was observed by LC-MS. The reaction mixture was diluted with EtOAc (150 mL) and the solid was collected via filtration and washed with EtOAc yielding 820 mg of desired (60% yield). LCMS calculated for C12H7BrFN3 292.1, found 292.23: [M+].

Provenance & Evidence